UDP‐galactopyranose mutase: an unexpected ligand‐binding mode leads to model of substrate binding
نویسندگان
چکیده
منابع مشابه
Ligand binding and substrate discrimination by UDP-galactopyranose mutase.
Galactofuranose (Galf) residues are present in cell wall glycoconjugates of numerous pathogenic microbes. Uridine 5'-diphosphate (UDP) Galf, the biosynthetic precursor of Galf-containing glycoconjugates, is produced from UDP-galactopyranose (UDP-Galp) by the flavoenzyme UDP-galactopyranose mutase (UGM). The gene encoding UGM (glf) is essential for the viability of pathogens, including Mycobacte...
متن کاملInvestigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.
The development of small molecules that recognize specific DNA and RNA sequences or structures remains a critical challenge. If cell-permeable, such agents might allow the regulation of genes for therapeutic purposes or the targeting of DNA or RNA sites known to play some other roles in causing disease. A few general approaches to the recognition of double-helical DNA, base mismatches, G-quarte...
متن کاملUnexpected Banking Loan Losses in an Estimated DSGE Model
In spite of realizing more loss than expected and reserved provision in loaning process, some of our banks avoid recognizing the losses, through extension of the loan contracts and consequently do not shift the realized losses to their capital. With this in mind, the major objective of this study is to design a frame-work, through which we can explain the differences between the results of t...
متن کاملcost benefits of rehabilitation after acute coronary syndrome in iran; using an epidemiological model
چکیده ندارد.
Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation.
The farnesoid X receptor (FXR), a member of the nuclear hormone receptor family, plays important roles in the regulation of bile acid and cholesterol homeostasis, glucose metabolism, and insulin sensitivity. There is intense interest in understanding the mechanisms of FXR regulation and in developing pharmaceutically suitable synthetic FXR ligands that might be used to treat metabolic syndrome....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.1012.9